From San Francisco International Airport (SFO)
The hotel is about 2 miles south of the San Francisco airport (near the Broadway exit from Highway 101 in Burlingame).

The most convenient way to and from the airport is via the free hotel shuttle. The Hyatt Regency shuttle runs every 10-15 minutes (every 30 minutes from midnight to 5 a.m.).

You can also take a ride-share (Uber/Lyft), taxi, or shared-ride van to the hotel.

San Francisco Airport information

From Oakland Airport (OAK) and San Jose (Mineta) Airport (SJC)
Both airports are about 30 miles from the hotel.

From Oakland Airport, you can take public transportation. The Oakland Airport BART station is right outside Terminal 1. Take the BART airport connector train to the Coliseum BART Station. From there, take a BART train to San Francisco Airport, then catch the free Hyatt Regency shuttle to the hotel.
Cost: About $21 one-way
Travel time: 60-75 minutes

You can take a door-to-door shuttle to the hotel from both Oakland Airport and San Jose Airport. Choose any shuttle company with service to San Mateo County. Walk to the shuttle area outside the terminal and inform the dispatcher of your destination. (On the return trip, an advance reservation is required; ask the hotel concierge for assistance.)
Cost: About $60 one-way
Travel time: 40-60 minutes

Oakland Airport information
San Jose Airport information

Via public transportation
From San Francisco and the East Bay: Take a BART train to San Francisco Airport, then catch the free Hyatt Regency shuttle to the hotel.

From the Peninsula and South Bay: Take Caltrain to the Burlingame station, then catch the free Burlingame Trolley to the hotel. (Note: Santa Clara VTA route 10, the airport flyer, links San Jose Airport to Caltrain at the Santa Clara station.)

Bay Area Rapid Transit information (includes online trip planner)
Caltrain (includes station map with access into San Francisco)
Citymapper (great little transportation map good for many cities and areas)